Could Your Depression Be Related to Your Medication?

After two weeks of taking isotretinoin, an acne medicine, 19-year-old Joe began experiencing fatigue, lack of motivation, sleep problems, and crying spells. He was diagnosed with depression (something his doctor eventually believed was related to his use of isotretinoin). When Joe stopped taking the medicine, his symptoms quickly resolved.

In 2005, the Food and Drug Administration (FDA) issued a warning about isotretinoin, stating that it can cause symptoms of depression or suicidal thoughts. But numerous other medicines can also cause depression.

Symptoms of Depression

Could Your Depression Be Related to Your MedicationDepression is a condition characterized by feelings of profound sadness and a lack of interest in formerly enjoyable activities. Symptoms may include:

  • Persistent feelings of sadness, anxiety, or emptiness
  • Hopelessness
  • Feeling guilty, worthless, or helpless
  • Loss of interest in hobbies and activities
  • Loss of interest in sex
  • Feeling tired
  • Trouble concentrating, remembering, making decisions
  • Trouble sleeping, waking up too early, or oversleeping
  • Eating more or less than usual
  • Weight gain or weight loss
  • Thoughts of death or suicide, with or without suicide attempts
  • Restlessness or irritability
  • Physical symptoms that defy standard diagnosis and do not respond well to medical treatment

Medications Reported to Cause Depression

This table, from the The Medical Letter on Drugs and Therapeutics, provides examples of medicines that can cause depression:

Drug General Treatment Uses
Acyclovir (Zovirax) Chickenpox, shingles, herpes
Amphetamines Attention deficit hyperactivity disorder, narcolepsy
Anabolic steroids Often used illicitly by athletes to build muscle
Anticonvulsants Seizures, epilepsy, pain
Asparaginase (Elspar) Blood cancers
Baclofen (Lioresal) Muscle spasms, cramps, muscle tightness from multiple sclerosis, cerebral palsy, and spinal cord injuries
Barbiturates Seizures, insomnia
Benzodiazepines Anxiety, convulsions, insomnia
Beta-adrenergic blockers (beta blockers) Cardiovascular conditions
Bromocriptine (Parlodel) Menstrual problems, lactation problems, infertility, Parkinson’s disease, acromegaly, tumors of the pituitary gland
Calcium channel blockers Cardiovascular conditions
Corticosteroids Inflammatory conditions, asthma, arthritis, cancer
Cycloserine (Seromycin) Tuberculosis
Dapsone (Aczone) Leprosy, dermatitis herpetiformis
Digitalis (Lanoxin, digoxin, digitoxin) Cardiac conditions
Disopyramide (Norpace) Abnormal heart rhythms
Disulfiram (Antabuse) Alcohol abuse
Estrogens Menopause, prevention of osteoporosis, certain cancers
Fluoroquinolone antibiotics Bacterial infections in different parts of the body
Histamine H2-receptor antagonists Acid-related diseases of the gastrointestinal tract
HMG-CoA reductase inhibitors (statins) Lipid disorders
Interferon alfa (Roferon-A) Hairy cell leukemia, malignant melanoma, AIDS-related Kaposi’s sarcoma, growths in the respiratory tract, genital warts, certain types of hepatitis
Isotretinoin (Accutane) Severe acne, rosacea, other skin diseases
Levodopa (Dopar) Parkinson’s disease
Mefloquine (Lariam) Malaria prevention and treatment
Methyldopa (Aldomet) High blood pressure
Metoclopramide (Reglan) Diabetic gastroparesis, nausea, vomiting, fullness after meals, loss of appetite, heartburn
Metrizamide (Amipaque) For diagnosis of brain disorders, cardiac disease, central nervous system disorders, urinary tract disorders, vascular disease
Metronidazole (Flagyl) Infections
Narcotics Pain
Nonsteroidal anti-inflammatory drugs Arthritis, inflammatory conditions, pain
Pergolide (Permax) Parkinson’s disease
Progestins, implanted (Norplant) Birth control
Sulfonamides Infections
Thiazide diuretics High blood pressure
Vinblastine (Velban) Certain cancers

Other medicines may also cause depression. Talk to your doctor and pharmacist about your concerns.

Medication or Depression: Which Comes First?

Do certain medicines cause depression, or are people with depression more apt to take certain medicines? The relationship is not always clear.

According to the National Institute of Mental Health, people taking medicines that are linked to depression often have chronic conditions, such as cancer or cardiovascular disease, or an unrecognized mental illness, which may also put them at risk for depression. Furthermore, they may also be dealing with psychosocial factors, such as disability, unemployment, and other stressors that increase their risk for depression.

It is also known that people with a personal history of depression are more likely to experience depression as an adverse reaction to certain medicines. Nonetheless, drug-induced depression does not generally meet diagnostic criteria for “major depressive disorder.” Instead, it more commonly resembles “atypical depression,” suggesting that drugs may indeed be the cause in affected individuals.

The elderly may be at higher risk for drug-induced depression. Many elderly people take multiple medicines, and it is possible that drugs which may not cause depression when given by themselves could do so when given in combination. While many drugs (as in the above list) have been thought to be able to cause depression, rigorous studies provide at least limited evidence for causation in only a few. Among these better-proven causes are:

  • Mefloquine
  • Alpha interferon
  • Interleukin-2
  • Gonadotropin-releasing hormone agonists
  • Progestin-releasing implanted contraceptives
  • Corticosteroids
  • Propranolol

Of these drugs, only the last three are commonly prescribed. The others are typically used to treat serious or life-threatening conditions in people under close medical supervision.

Talk to Your Doctor

Most people who take any of the medicines above will not become depressed. And not all cases of depression in people taking these medicines will be a result of the medicine. However, if you are taking one or more of these medicines and have been feeling unusually sad, talk to your doctor about it. But even if you are not taking a medicine on the list, talk to your doctor about any symptoms of depression you may have. Whatever the cause, treatment can make you feel better, be more productive, and be better able to overcome whatever other health problems you might have.


Beers MH, Passman LJ. Antihypertensive medications and depression. Drugs. 1990;40(6):792-799.

Bender, K. New warning of depression with Accutane could apply to other medications. Psychiatric Times . 1998;15:1-7.

Kotlyar M, Dysken M, AdsonDE. Update on drug-induced depression in the elderly. Am J Geriatr Pharmacother. 2005;3:288-300.

Some drugs that cause psychiatric symptoms. Medical Letter. 1998;40:21-24.

United States Pharmacopeial Convention. USP DI. 21st ed.Greenwood Village,CO: Micromedex; 2001.


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